No

George (or another reaper) reaps Joy/Reggie - Far too depressing
Delores dies - She is far too wonderful a character to lose, Would rather she remain George/Millie's connection to the living world than become a reaper.

Yes

Crystal revealed as a reaper - perhaps, or even better as the Head Reaper/Angel of Death/Deliverer of the list/ GOD herself.
Roxy's boyfriend
Rube romance with a living person - I love it when the leader/father breaks the rules.
Cynthia Stevenson hints on the DVD commentary that she would love to see Joy and Rube form a relationship, or a close friendship.
Daisy's backstory - Are her hollywood stories true? Did she have a sister who was murdered? Was she herself murdered.